Indocin
Indocin (generic name: Indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. It is similar to ibuprofen (Motrin) and naproxen (Naprosyn, Aleve). Indomethacin works by reducing the production of prostaglandins. Prostaglandins are chemicals that the body uses to cause fever, pain and inflammation. Indomethacin blocks the enzymes that make prostaglandins (cyclooxygenase 1 and 2) and thereby reduces the levels of prostaglandins. As a result, fever, pain and inflammation are reduced. Indomethacin is available in a sustained (slow) release form (Indocin-SR). Indomethacin was first approved by the FDA in January, 1965.
Cholestyramine (Questran) and colestipol (Colestid) may decrease the absorption of Indocin (indomethacin) by acting as a mechanical barrier to absorption. Indocin and other NSAIDs may decrease the elimination of lithium by the kidneys and, therefore, increase the blood level of lithium, which could lead to lithium toxicity.
Indocin side effects
The most common side effects are nausea, vomiting, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness. Indomethacin may cause or worsen stomach or intestinal bleeding or ulcers. It may lead to perforation of the intestine. Indomethacin also can increase blood pressure and decrease kidney function. Individuals who have nasal polyps or are allergic to aspirin or other NSAIDs should not use indomethacin because there is an increased risk of severe allergic reactions in these individuals.
